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DOSAGE
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Presbyopia | 1 gtt qDay Daily Max
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GENERIC
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pilocarpine hydrochloride ophthalmic solution 1.25%
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INDICATIONS
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indicated for the treatment of presbyopia in adults.
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MECHANISM OF ACTION
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Pilocarpine hydrochloride is a cholinergic muscarinic agonist which activates muscarinic receptors located at smooth muscles such as the iris sphincter muscle and ciliary muscle. VUITY contracts the iris sphincter muscle, constricting the pupil to improve near and intermediate visual acuity while maintaining some pupillary response to light. VUITY also contracts the ciliary muscle and may shift the eye to a more myopic state
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MICROBIOLOGY
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Pilocarpine hydrochloride is a cholinergic muscarinic agonist which activates muscarinic receptors located at smooth muscles such as the iris sphincter muscle and ciliary muscle. VUITY contracts the iris sphincter muscle, constricting the pupil to improve near and intermediate visual acuity while maintaining some pupillary response to light. VUITY also contracts the ciliary muscle and may shift the eye to a more myopic state
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CONTRAINDICATIONS & WARNINGS
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(1) Poor Illumination: Exercise caution in night driving and other hazardous occupations in poor illumination (2) Risk of Retinal Detachment: Rare cases of retinal detachment have been reported with other miotics; patients should be advised to seek immediate medical care with sudden onset of vision loss. (3) Iritis: Caution is advised in patients with iritis.
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PEDIATRIC USE
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Presbyopia does not occur in the pediatric population
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PREGNANCY
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There are no adequate and well-controlled studies of VUITY administration in pregnant women to inform a drug-associated risk
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NOTE
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Systemic toxicity following topical ocular administration of pilocarpine is rare, but occasionally patients who are sensitive may develop sweating and gastrointestinal overactivity. Accidental ingestion can produce sweating, salivation, nausea, tremors and slowing of the pulse and a decrease in blood pressure. In moderate overdosage, spontaneous recovery is to be expected and is aided by intravenous fluids to compensate for dehydration. For patients demonstrating severe poisoning, atropine, the pharmacologic antagonist to pilocarpine, should be used
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Effective Use: 6 hours max, 1st hour is best, patients might need to rely on readers for fine print
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