Pred Forte (susp)

Pred Forte (susp)

Generic: prednisolone acetate 1.0%

Pred Forte (susp)
DOSAGE 1-2 gtts BID-QID. More often in the first 24-48hours, if increased dosing is necessary. Then Taper. If signs and symptoms fail to improve after 2 days, the patient should be re-evaluated
Anterior Uveitis Treatment (Mild/Moderate) Anterior Uveitis Treatment (Severe)
(1) Cyclopentolate 1% TID (2) PF 1% or Durezol 0.5% q1-6hrs, depending on severity, then taper QID x 1 week, TID x 1 week, then BID x 1 week. D/c when there is no AC reaction (1) Atropine 1% BID to QID (2) PF 1% or Durezol 0.5% q1-2 hours initial, consider a loading dosage q1min for 5 mins x 2 weeks, then taper QID x 1 week, TID x 1 week, then BID x 1 week. D/c when there is no AC reaction
Note: Long term, low dosage steroids can be used q1-2 days to keep inflammation recurring.
GENERIC prednisolone acetate 1.0%
SIZE 5mL,10mL,15mL
INDICATIONS PRED FORTE is indicated for the treatment of steroid-responsive inflammation of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe.
Suited for the more severe ocular inflammations, but is not adequate therapy for posterior uveitis or panuveitis. Can take several weeks to be fully effective
MECHANISM OF ACTION Ketone based acetate corticosteroid
MICROBIOLOGY Prednisolone acetate is a glucocorticoid that, on the basis of weight, has 3 to 5 times the anti-inflammatory potency of hydrocortisone. Glucocorticoids inhibit the edema, fibrin deposition, capillary dilation, and phagocytic migration of the acute inflammatory response, as well as capillary proliferation, deposition of collagen, and scar formation.
CONTRAINDICATIONS & WARNINGS PRED FORTE suspension is contraindicated in acute untreated purulent ocular infections, in most viral diseases of the cornea and conjunctiva including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella, and also in mycobacterial infection of the eye and fungal diseases of ocular structures. Known or suspected hypersensitivity
Elevated IOP, Posterior subcapsular cataract formation, Secondary ocular infection, Perforation of the globe
PEDIATRIC USE The safety and effectiveness in pediatric patients have been established.
PREGNANCY Category C. Teratogenic There are no adequate well-controlled studies in pregnant women. Prednisolone should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
NOTE Sometime OD consider Durezol since it is more potent than prednisolone acetate 1%. Pred Mild is the 1/8% preparation and is rarely prescribed