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1 yo and older: 1 gtt 2.5% in 5-minute intervals up to a maximum of 3 drops | To obtain a greater degree of mydriasis, use 10% strength.
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Less than 1 yo old: 1 gtt 2.5% in 3-5-minute intervals up to a maximum of 3 drop
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GENERIC
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phenylephrine hydrochloride 2.5%, 10 % Ophthalmic Solution
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SIZE
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2mL, 3mL, 5mL, 15mL (2.5%) | 2mL, 5 mL (10%)
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INDICATIONS
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Phenylephrine Hydrochloride Ophthalmic Solution is an alpha-1 adrenergic receptor agonist indicated to dilate the pupil
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MECHANISM OF ACTION
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Phenylephrine hydrochloride is an α-1 adrenergic agonist drug that is used in ophthalmology mainly for its mydriatic effect
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MICROBIOLOGY
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phenylephrine acts directly on α-adrenergic receptors in the eye, producing contraction of the dilator muscle of the pupil and constriction of the arterioles in the conjunctiva.
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CONTRAINDICATIONS & WARNINGS
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The 10% strength is contraindicated in: Patients with hypertension, or thyrotoxicosis. Pediatric patients less than 1 year of age due to increased risk of systemic toxicity
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PEDIATRIC USE
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Phenylephrine hydrochloride ophthalmic solution 10% is contraindicated in pediatric patients less than 1 year of age
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PREGNANCY
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Category C: Animal reproduction studies have not been conducted with topical phenylephrine. It is also not known whether phenylephrine can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Phenylephrine hydrochloride should be given to a pregnant woman only if clearly needed.
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NOTE
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Overdosage of phenylephrine may cause a rapid rise in blood pressure. It may also cause headache, anxiety, nausea, and vomiting, and ventricular arrhythmias. Prompt injection of a rapidly acting alpha-adrenergic blocking agent such as phentolamine has been recommended.
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