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DOSAGE
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1 or 2 gtts q2-4 hours for 7-10 days. In severe infections, dosage may be increased to as much as two drops q1hr
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GENERIC
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neomycin, polymyxin b, gramicidin
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INDICATIONS
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Neomycin and polymyxin B sulfates and gramicidin ophthalmic solution is indicated for the topical treatment of superficial infections of the external eye and its adnexa caused by susceptible bacteria. Such infections encompass conjunctivitis, keratitis and keratoconjunctivitis, blepharitis and blepharoconjunctivitis.
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MECHANISM OF ACTION
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Aminoglycoside/polypeptide Cell membrane disruption. Neomycin, an aminoglycoside, inhibits bacterial cell synthesis. Polymyxin B and Gramicidin increase bacterial cell membrane permeability.
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MICROBIOLOGY
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Neomycin is bactericidal for many gram-positive and gram-negative organisms. It is an aminoglycoside antibiotic which inhibits protein synthesis by binding with ribosomal RNA and causing misreading of the bacterial genetic code. Polymyxin B is bactericidal for a variety of gram-negative organisms. It increases the permeability of the bacterial cell membrane by interacting with the phospholipid components of the membrane. Gramicidin is bactericidal for a variety of gram-positive organisms. It increases the permeability of the bacterial cell membrane to inorganic cations by forming a network of channels through the normal lipid bilayer of the membrane. Neomycin sulfate, polymyxin B sulfate and gramicidin together are considered active against the following microorganisms: Staphylococcus aureus, streptococci, including Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae, Klebsiella-Enterobacter species, Neisseria species and Pseudomonas aeruginosa. The product does not provide adequate coverage against Serratia marcescens.
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CONTRAINDICATIONS & WARNINGS
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High incidence (10%) of type 4 delayed hypersensitivity reaction.
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PEDIATRIC USE
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Safety and effectiveness in pediatric patients have not been established
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PREGNANCY
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Category C Teratogenic Effects. Adequate animal reproductive studies have not been conducted with neomycin, polymyxin B or gramicidin. It is also not known whether this product can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. This product should be given to a pregnant woman only if clearly needed.
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NOTE
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Consider Polytrim or Besivance to avoid Neomycin allergy
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