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DOSAGE
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Ocular Infection: Instill 1/2" ribbon TID-QID into conjunctival sac
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Blepharitis: Apply to eyelashes BID to TID for 7 days
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GENERIC
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neomycin 0.35%, polymyxin B + dexamethasone 0.1%
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SIZE
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3.5g tube
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INDICATIONS
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Ocular steroids are indicated in inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe where the inherent risk of steroid use in certain infective conjunctivitides is accepted to obtain a diminution in edema and inflammation. They are also indicated in chronic anterior uveitis and corneal injury from chemical, radiation or thermal burns; or penetration of foreign bodies. The use of a combination drug with an anti-infective component is indicated where the risk of infection is high or where there is an expectation that potentially dangerous numbers of bacteria will be present in the eye.
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Off-Label for Blepharitis
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MECHANISM OF ACTION
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aminoglycoside, cationic detergent, corticosteroid: Aminoglycosides inhibit bacterial protein synthesis so are active against gram-positive species. Polymyxins bind to bacterial cell membrane increasing permeability so are active against gram-negative species. Corticosteroids inhibit arachidonic acid release .
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MICROBIOLOGY
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The particular anti-infective drug in this product is active against the following common bacterial eye pathogens: Staphylococcus aureus, Escherichia coli, Haemophilus influenzae, Klebsiella/Enterobacter species, Neisseria species, and Pseudomonas aeruginosa.
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This product does not provide adequate coverage against: Serratia marcescens and Streptococci, including Streptococcus pneumoniae.
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CONTRAINDICATIONS & WARNINGS
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MAXITROL* (neomycin and polymyxin B sulfates and dexamethasone ophthalmic ointment) is contraindicated in epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, varicella, and many other viral diseases of the cornea and conjunctiva. Mycobacterial infection of the eye. Fungal diseases of ocular structures.
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MAXITROL (neomycin and polymyxin B sulfates and dexamethasone ophthalmic ointment) is also contraindicated in individuals with known or suspected hypersensitivity to a component of the medication. (Hypersensitivity to the antibiotic component occurs at a higher rate than for other components.)
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PEDIATRIC USE
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Safety and effectiveness in pediatric patients have not been established.
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PREGNANCY
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Category C Dexamethasone has been shown to be teratogenic in mice and rabbits following topical ophthalmic application in multiples of the therapeutic dose. In the mouse, corticosteroids produce fetal resorptions and a specific abnormality, cleft palate. In the rabbit, corticosteroids have produced fetal resorptions and multiple abnormalities involving the head, ears, limbs, palate, etc. There are no adequate or well-controlled studies in pregnant women. However, prolonged or repeated corticoid use during pregnancy has been associated with an increased risk of intra-uterine growth retardation. MAXITROL* (neomycin and polymyxin B sulfates and dexamethasone ophthalmic ointment) should be used during pregnancy only if the potential benefit to the mother justifies the potential risk to the embryo or fetus. Infants born of mothers who have received substantial doses of corticosteroids during pregnancy should be observed carefully for signs of hypoadrenalism.
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NOTE
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Hypersensitivity to neomycin is common. Glaucoma risk with extended use.
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Other Generic name: Neo Poly Dex Ointment, NPD Ophthalmic Ointment
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