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DOSAGE
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Surgery (Pain/Inflammation): 1/2" ribbon applied QID beginning 24 hours after surgery x 2 weeks
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Contact Dermatitis (skin): Lotemax 0.50% ung apply to periocular area BID-TID x 4-5 days
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GENERIC
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loteprednol etabonate 0.5%
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INDICATIONS
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LOTEMAX ointment is a corticosteroid indicated for the treatment of post-operative inflammation and pain following ocular surgery
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Use off-Label for: Gel often used for inflammatory dry eye, uveitis, inflamed pinguecula and pterygium. Ointment/Gel may be used for contact dermatitis.
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MECHANISM OF ACTION
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Ester based "soft" steroid
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MICROBIOLOGY
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Corticosteroids inhibit the inflammatory response to a variety of inciting agents and probably delay or slow healing. They inhibit the edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen, and scar formation associated with inflammation. While glucocorticoids are known to bind to and activate the glucocorticoid receptor, the molecular mechanisms involved in glucocorticoid/glucocorticoid receptor-dependent modulation of inflammation are not clearly established. However, corticosteroids are thought to inhibit prostaglandin production through several independent mechanisms.
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CONTRAINDICATIONS & WARNINGS
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LOTEMAX ointment, as with other ophthalmic corticosteroids, is contraindicated in most viral diseases of the cornea and conjunctiva including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella, and also in mycobacterial infection of the eye and fungal diseases of ocular structures.
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PEDIATRIC USE
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Safety and effectiveness in pediatric patients have not been established.
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PREGNANCY
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Category C. Teratogenic in rabbits at 1.2x the normal human dose. There are no adequate and well-controlled studies with loteprednol etabonate in pregnant women.
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NOTE
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Prolonged use may cause glaucoma, cataracts, bacterial and fungal overgrowth. Contact lenses should not be used during the course of therapy. Ointment comes in a tube and is unpreserved.
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