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DOSAGE
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Conjunctivitis/Keratitis: Instill one or two drops into the affected eye(s) every four hours. In severe infections dosage may be increased to as much as two drops every hour.
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INDICATIONS
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Gentamicin sulfate ophthalmic solution is indicated in the topical treatment of ocular bacterial infections including conjunctivitis, keratitis, keratoconjunctivitis, corneal ulcers, blepharitis, blepharoconjunctivitis, acute meibomianitis, and dacryocystitis.
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MECHANISM OF ACTION
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Aminoglycoside. Prevents bacterial protein synthesis by binding to s30 ribosomal subunit
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MICROBIOLOGY
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Gentamicin sulfate is active in vitroagainst many strains of the following microorganisms: Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus pneumoniae, Enterobacter aerogenes Escherichia coli; Haemophilus influenzae, Klebsiella pneumoniae, Neisseria gonorrhoeae, Pseudomonas aeruginosa, and Serratia marcescens.
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CONTRAINDICATIONS & WARNINGS
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Gentamicin sulfate ophthalmic solution is contraindicated in patients with known hypersensitivity to any of its components.
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PREGNANCY
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Pregnancy category D |Gentamicin has been shown to depress body weights, kidney weights and median glomerular counts in newborn rats when administered systemically to pregnant rats in daily doses approximately 500 times the maximum recommended ophthalmic human dose. There are no adequate and well-controlled studies in pregnant women. Gentamicin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
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NOTE
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BAK preserved | also available in injection solution and cream form
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