Bactrim
| Bactrim | |
|---|---|
| DOSAGE | Adults | 1 BACTRIM DS (double strength) TAB or 2 BACTRIM tablets q12 hours for 10 to 14 days |
| Hordeola and preseptal cellulitis | 1 tab 400mg/80mg or 800mg/160mg BID-TID x 7-10 days | |
| GENERIC | Sulfamethoxazole / Trimethoprim |
| SIZE | Tablets (400/80mg, 800/160mg) |
| INDICATIONS | To reduce the development of drug-resistant bacteria and maintain the effectiveness of Bactrim (sulfamethoxazole and trimethoprim) tablets and other antibacterial drugs, Bactrim (sulfamethoxazole and trimethoprim) tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. |
| MECHANISM OF ACTION | Combination antibiotic |
| MICROBIOLOGY | Sulfamethoxazole inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) |Trimethoprim blocks the production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the required enzyme, dihydrofolate reductase. Thus, sulfamethoxazole and trimethoprim blocks two consecutive steps in the biosynthesis of nucleic acids and proteins essential to many bacteria. |
| CONTRAINDICATIONS & WARNINGS | BACTRIM is contraindicated in the following situations: •a known hypersensitivity to trimethoprim or sulfonamides •history of drug-induced immune thrombocytopenia with use of trimethoprim and/or sulfonamides •documented megaloblastic anemia due to folate deficiency •pediatric patients less than 2 months of age •marked hepatic damage •severe renal insufficiency when renal function status cannot be monitored •concomitant administration with dofetilide |
| PEDIATRIC USE | Contraindicated for infants younger than 2 months of age |
| PREGNANCY | Category C | No large, well-controlled studies on the use of sulfamethoxazole and trimethoprim in pregnant women |
| NOTE | Also available in double strength (Bactrim DS) |
| Not for use with sulfa allergy. | |