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DOSAGE
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Preseptal cellulitis
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Mild to Moderate (adult) | 1 tab PO 500mg BID (q12hours) or 1 tab 250mg q8hrs x 10-14 days course
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Severe (adult) | 1 tab PO 875mg (q12hr) or 1 tab 500mg q8hrs x 10-14 days course
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Mild to Moderate (Kid) | 1 tab PO 25-45 mg/kg/day in two divided dosages for children, max daily dosage of 90 mg/kg/day
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Add on Warm compress TID/PRN, Polysorin Ung QID (Optional if conjunctivitis present) + Nasal decongestants if sinusitis is present
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Dacryocystitis (inflammation of the Lacrimal Sac)
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Mild/Moderate (adult): 1 tab PO 875mg BID or 1 tab 500mg TID x 10-14 days course
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Mild to Moderate (Kid): 1 tab PO 25-45 mg/kg/day in two divided dosages for children, max daily dosage of 90 mg/kg/day
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Add on Warm compress QID with massage to inner canthal region, any AB gtts (ex: Ocuflox 0.3%) QID (Optional if conjunctivitis present) + Nasal decongestants if sinusitis is present + OTC oral Pain PRN + Consider referral for incision/drainage
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GENERIC
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amoxicillin, clavulanate
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SIZE
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Tablets(250, 500, 875mg), Chewable(125, 200, 250, 400mg), Suspension(125, 200, 250, 400mg).
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INDICATIONS
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AUGMENTIN is an oral antibacterial combination consisting of amoxicillin and the beta lactamase inhibitor, clavulanate potassium (the potassium salt of clavulanic acid). Used against ß-lactamase producing strains of H. influenzae, M. catarrhalis, S. aureus, E. coli, Klebsiella spp as well as ampicillin-susceptible organisms particularly S. pneumoniae
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MECHANISM OF ACTION
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moderate-spectrum ß-lactam antibiotic / ß-lactamase inhibitor
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MICROBIOLOGY
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Inhibits cross-linkage between the peptidoglycan polymer chains of bacterial cell wall. / Inhibits bacterial ß-lactamase enzyme.
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CONTRAINDICATIONS & WARNINGS
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AUGMENTIN is contraindicated in patients with a history of serious hypersensitivity reactions (e.g., anaphylaxis or Stevens-Johnson syndrome) to amoxicillin, clavulanate or to other beta lactam antibacterial drugs (e.g., penicillins and cephalosporins) |Cholestatic Jaundice/Hepatic Dysfunction | Patients with a previous history of cholestatic jaundice/hepatic dysfunction associated with AUGMENTIN.
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PEDIATRIC USE
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Dosing of AUGMENTIN should be modified in pediatric patients aged <3 months
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The safety and effectiveness of AUGMENTIN Powder for Oral Suspension and Chewable Tablets have been established in pediatric patients. Use of AUGMENTIN in pediatric patients is supported by evidence from studies of AUGMENTIN Tablets in adults with additional data from a study of AUGMENTIN Powder for Oral Suspension in pediatric patients aged 2 months to 12 years with acute otitis media. [see Clinical Studies]
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Because of incompletely developed renal function in neonates and young infants, the elimination of amoxicillin may be delayed; clavulanate elimination is unaltered in this age group. Dosing of AUGMENTIN should be modified in pediatric patients aged <12 weeks (<3 months). [see DOSAGE AND ADMINISTRATION]
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PREGNANCY
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Teratogenic Effects: Pregnancy Category B.
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NOTE
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If patient is allergic to Penicillin, then use Septra DS / Bactrim (generic: sulfamethoxazole/trimethoprim)
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Mild/Moderate (Adult): 1 single strength tab (400mg/80mg) q12hr x 10-14 days.
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Acute/Severe (Adult): 1 DS tab(800mg/160mg) q12hr x 10-14 days.
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Mild/Moderate (Age 5 and younger): 8-12 mg/kg/day trimethoprim with 40-60 mg/kg/day sulfamethoxazole PO into 2 divided doses x 10-14 days
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The q12hr regimen is preferred with a full 10 day course is recommended.
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