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Mild/Moderate | 1 Tab PO 250mg q8hr or 500mg q12hr.
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Severe | 1 Tab PO 500mg q8hr or 875mg q12hr
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SIZE
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Tablets (500, 875mg) Capsule(250,500mg) Chewable(125mg, 200mg,250mg, 400mg) Suspension(200mg/5ml, 400mg/5ml)
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INDICATIONS
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Indicated in the treatment of skin and skin structure infections due to ß-lactamase producing strains Streptococcus spp. (α- and ß-hemolytic strains only), Staphylococcus spp., or E. coli. Susceptible to degradation by ß-lactamase-producing bacteria.Not useful for Pseudomonas aeruginosa.
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MECHANISM OF ACTION
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moderate-spectrum ß-lactam antibiotic (ampicillin analog)
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MICROBIOLOGY
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ß-lactam antibiotics bind to transpeptidase (used by bacteria in cell wall synthesis).
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CONTRAINDICATIONS & WARNINGS
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Allergy to any of the penicillins. (Caution if history of cephalosporin allergy.)
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PEDIATRIC USE
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Adults and Pediatric Patients > 3 months Because of incompletely developed renal function in neonates and young infants, the elimination of amoxicillin may be delayed. Dosing of AMOXIL should be modified in pediatric patients 12 weeks or younger ( ≤ 3 months) See Chart below
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PREGNANCY
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Teratogenic Effects: Pregnancy Category B. Reproduction studies have been performed in mice and rats at doses up to 2000 mg/kg (3 and 6 times the 3 g human dose, based on body surface area). There was no evidence of harm to the fetus due to amoxicillin. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, amoxicillin should be used during pregnancy only if clearly needed.
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NOTE
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Consider Septra (Monarch pharma) or Bactrim (Roche) when penicillin allergy is encountered.
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