Alomide

Alomide
DOSAGE 1-2 gtts QID for up to 3 months.
GENERIC lodoxamide tromethamine 0.1%
SIZE 10mL
INDICATIONS ALOMIDEĀ® (lodoxamide tromethamine ophthalmic solution) 0.1% is indicated in the treatment of the ocular disorders referred to by the terms vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis.
MECHANISM OF ACTION Mast Cell Stabilizer (1st generation)
MICROBIOLOGY Prevents antigen-stimulated release of histamine and other inflammatory mediators.
Lodoxamide tromethamine is a mast cell stabilizer that inhibits the in vivo Type I immediate hypersensitivity reaction. Lodoxamide therapy inhibits the increases in cutaneous vascular permeability that are associated with reagin or IgE and antigen-mediated reactions. Stabilize rodent mast cells and prevent antigen-stimulated release of histamine. In addition, lodoxamide prevents the release of other mast cell inflammatory mediators (i.e., SRS-A, slow-reacting substances of anaphylaxis, also known as the peptido-leukotrienes) and inhibits eosinophil chemotaxis. Although lodoxamide's precise mechanism of action is unknown, the drug has been reported to prevent calcium influx into mast cells upon antigen stimulation. Lodoxamide has no intrinsic vasoconstrictor, antihistaminic, cyclooxygenase inhibition, or other anti-inflammatory activity.
CONTRAINDICATIONS & WARNINGS Hypersensitivity to any component of this product.
PEDIATRIC USE Safety and effectiveness in pediatric patients below the age of 2 years have not been established.
PREGNANCY Category B Reproduction studies with lodoxamide tromethamine administered orally to rats and rabbits in doses of 100 mg/kg/day (more than 5000 times the proposed human clinical dose) produced no evidence of developmental toxicity. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, ALOMIDEĀ® (lodoxamide tromethamine ophthalmic solution) 0.1% should be used during pregnancy only if clearly needed.
NOTE Not suitable for acute allergy relief. Still available, but combination drugs would normally be used instead.